Researchers Claim They Created a Substance That Regrows Hair

Living With Hair Loss

Some people really love their hair. They love styling it in various ways, dyeing it, braiding it, and just using it as a way to express their personality. For those people, the realization that they’re going bald can be downright devastating, but even for those less enthusiastic about their locks, the loss can be quite alarming. Even more alarming? There’s no cure for baldness.

According to the American Hair Loss Association (AHLA), androgenetic alopecia — commonly known as male pattern baldness (MPB) — accounts for more than 95 percent of hair loss in men. By the age of 35, an estimated two-thirds of American men will experience some degree of hair loss, and 25 percent are expected to begin the process before they’re 21.

Of course, balding doesn’t only affect men. Forty percent of Americans that experience hair loss are women, and as the AHLA explains on their website, female hair loss is considered less socially acceptable than male hair loss.

The AHLA reports that 99 percent of products marketed in the hair loss treatment industry are ineffective, so most androgenetic alopecia sufferers simply have to learn to live without their hair. However, a team of South Korean scientists now claim they’ve created a biochemical substance that promotes hair growth and could eventually produce a cure for baldness.

Enter PTD-DMB

While studying hair loss and hair follicles, Choi Kang-yeol from Yonsei University in Seoul and his team discovered that those suffering from the condition had a significant amount of the CXXC5 protein in their scalp. The researchers learned that when that protein combines with the Dishevelled protein, they prevent the regeneration of hair follicles.

To prevent that binding, the team created PTD-DMB.

“We have found a protein that controls the hair growth and developed a new substance that promotes hair regeneration by controlling the function of the protein,” Choi told Business Korea. “We expect that the newly developed substance will contribute to the development of a drug that not only treats hair loss but also regenerate damaged skin tissues.”

The team tested PTD-DMB on mice, and after 28 days of applications, they noticed new hair follicle growth on the mice. They are now testing the substance on other animals to determine its toxicity. If those PTD-DMB tests yield positive results, the next step would be to start working toward the development of a drug and human trials.

Though promising, this research has a long ways to go before it could be used by people as a cure for baldness. Still, hair loss can have a devastating impact on one’s self-image and emotional well-being, and anything that could enabled a person to be comfortable with their appearance is absolutely worth exploring.

The post Researchers Claim They Created a Substance That Regrows Hair appeared first on Futurism.

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Scientists Have Discovered This Drug Fixes Cavities and Regrows Teeth

Goodbye, Fillings

Dental fillings may soon be left in the ash heap of history, thanks to a recent discovery about a drug called Tideglusib. Developed for and trialled to treat Alzheimer’s disease, the drug also happens to promote the natural tooth regrowth mechanism, allowing the tooth to repair cavities.

Tideglusib works by stimulating stem cells in the pulp of teeth, the source of new dentine. Dentine is the mineralized substance beneath tooth enamel that gets eaten away by tooth decay.

Teeth can naturally regenerate dentine without assistance, but only under certain circumstances. The pulp must be exposed through infection (such as decay) or trauma to prompt the manufacture of dentine. But even then, the tooth can only regrow a very thin layer naturally—not enough to repair cavities caused by decay, which are generally deep. Tideglusib changes this outcome because it turns off the GSK-3 enzyme, which stops dentine from forming.

Image Credit: ales_kartal/Pixabay
Image Credit: ales_kartal/Pixabay

In the research, the team inserted small, biodegradable sponges made of collagen soaked in Tideglusib into cavities. The sponges triggered dentine growth and within six weeks, the damage was repaired. The collagen structure of the sponges melted away, leaving only the intact tooth.

Thus far, the procedure has only been used in mouse teeth. Yet as King’s College London Dental Institute Professor and lead author Paul Sharpe told The Telegraph, “Using a drug that has already been tested in clinical trials for Alzheimer’s disease provides a real opportunity to get this dental treatment quickly into clinics.”

He added, “The simplicity of our approach makes it ideal as a clinical dental product for the natural treatment of large cavities, by providing both pulp protection and restoring dentine.”

The post Scientists Have Discovered This Drug Fixes Cavities and Regrows Teeth appeared first on Futurism.

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