“Intestine-Chip” Could Help Patients With Diseases Like Crohn’s

Organ-on-a-Chip

Patients with debilitating gastrointestinal diseases like Crohn’s disease, ulcerative colitis, and irritable bowel syndrome often have to try several costly treatments before they find one that works for them. These drugs can cause individuals painful side effects or ultimately be ineffective for their personal conditions. However, a new testing tool called an “Intestine-Chip” could save patients this pain and cost.

Intestinal lining cells created from an individual’s adult stem cells can be placed on a chip and mirror what is happening inside that individual’s body, according to a study from researchers at the Cedars-Sinai Board of Governors Regenerative Medicine Institute and Emulate, Inc. in Boston.

After being placed in a chip, intestine lining cells form folds like they do in the human body. Image Credit: Cedars-Sinai Board of Governors Regenerative Medicine Institute
After being placed in a chip, intestine lining cells form folds like they do in the human body. Image Credit: Cedars-Sinai Board of Governors Regenerative Medicine Institute

So, instead of testing drugs within a patient, you could test them on the Intestine-Chip first, protecting the patient from needlessly experiencing negative side effects. This could also reduce the amount of drug used, the difficulty of the application, and potentially the cost of the testing. This study was recently published in the journal Cellular and Molecular Gastroenterology and Hepatology.

Improving Medicine

Not only would Intestine-Chip allow researchers to better test drugs for patients, it could also give researchers more control in studies of these cells. Because the cells are on a chip and in a controlled environment, researchers can more easily study how they interact with immune cells and blood cells (as well as drugs) and better understand cell function.

“This is an important advance in personalized medicine.” -Clive Svendsen

Additionally, the fact that the chip uses stem cells allows doctors to study a patient’s intestinal lining without having to perform invasive surgery to obtain a tissue sample, Clive Svendsen, director of the Cedars-Sinai Board of Governors Regenerative Medicine Institute and a co-author of the study, said in a press release. And the process is good for more than one test, too.

“We can produce an unlimited number of copies of this tissue and use them to evaluate potential therapies,” Svendsen said in the press release. “This is an important advance in personalized medicine.”

Replicating organs on chips is not a new concept. Scientists are exploring this type of research with a variety of organs, even the human brain. Beyond improving and advancing personalized medicine, it could cut testing costs and one day replace animal testing.

The post “Intestine-Chip” Could Help Patients With Diseases Like Crohn’s appeared first on Futurism.

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How ad-free subscriptions could solve Facebook

The Best Guide To Selling Your Old Phones With High Profit

 At the core of Facebook’s “well-being” problem is that its business is directly coupled with total time spent on its apps. The more hours you pass on the social network, the more ads you see and click, the more money it earns. That puts its plan to make using Facebook healthier at odds with its finances, restricting how far it’s willing to go to protect us from the harms… Read More
Mobile – TechCrunch

911 Wasn’t Set Up With Cell Phones In Mind. Google Could Change that.

When the 911 emergency number was set up in 1968, there was no way to know how cellphones would change the way people use the service. Today, it’s still difficult for operators to pinpoint the exact location of callers to send out help – but Google could change all that.

The search giant has been testing out a way to use the technology that identifies the user’s location in Google Maps to help out the emergency services. As reported by the Wall Street Journal, a sample of 911 calls made using Android phones over the course of December 2017 and January 2018 saw geolocation data sent directly to the operator.

Currently, carriers can detect the location of a device by triangulating their distance from several cell phone towers, but this isn’t particularly accurate.  The study found that Google’s data gave an average location estimate radius of 121 feet, whereas carrier data averaged out at 522 feet.

At present, it falls to the operator to find out the exact location emergency responders need to be sent to from the caller. Given that they might be flustered, or potentially in a place they’re not familiar with, this can be a difficult prospect.

In this kind of situation, a slight improvement on the response time can be life-saving. Research published by the Federal Communications Commission suggests that as many as 10,000 lives could be saved annually if emergency response times were improved by just one minute.

Google has had the technology to provide this service for some time – it was rolled out in the U.K. and Estonia in July 2016, according to a report from Ars Technica. Many feel uncomfortable with the idea of allowing their smartphone to track their location, but in emergency circumstances, it’s easy to see the benefits.

The post 911 Wasn’t Set Up With Cell Phones In Mind. Google Could Change that. appeared first on Futurism.

Futurism

How the private space industry could take over lower Earth orbit — and make money off it

The Trump administration wants to end direct NASA funding for the International Space Station by 2025 — but that doesn’t necessarily mean the US will stop sending people into orbit around Earth by then. Instead, NASA hopes to transition the domain of lower Earth orbit, where the space station resides, to the commercial space industry over the next seven years. But what would it take for private space companies to take over this area of space — and what exactly would they do up there?

An option would be for one or more companies to take over full-time management of the International Space Station (ISS). But the orbiting lab is expensive to fly: NASA spends between $ 3 billion and $ 4 billion each year to keep the station afloat, and that’s…

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Why LCD iPhone X Plus Sales Could Shatter 100 Million Units in a Flash

Why LCD iPhone X Plus Sales Could Shatter 100 Million Units

Various reports have come out all guns blazing and predicted that Apple is likely to ship up to 100 million units of 6.1-inch LCD iPhone X Plus which is all geared up to hit the floor later this year. Though the staggering number may have been a huge thunder for many and even caused sleepless nights for the rivals, I’m yet to find the forecast extraordinary! So, what makes the LCD iPhone 2018 such massive crowd favorites?

Well, several factors augur well for the smartphone. And of them is the ability to offer flagship features at a much less price.

Why LCD iPhone X Plus Sales Could Shatter 100 Million Units

Why Apple May Ship 100 Million Units of 6.1-Inch LCD iPhone X Plus

No one doubts the elegance and superiority of iPhone X, which has been branded as the best product Apple has ever released by many experts. Even hardcore critics have admitted being charmed by the smartphone. But the unexpected low demand after a beautiful holiday season has surprised many—including me. After all, the slashing of production target by a half from a mammoth 40 million units to around 20 million units is unbelievable.

I believe it’s the high price that’s proving to be the wrecker-in-chief. Had the price of the iPhone X variants started from $ 750–$ 800, Apple would have sold out a record number of iPhones. Though iPhone 8 and 8 Plus are available for that price point, nobody wants them as they look completely worn out.

And that brings me to 6-1-inch LCD iPhone! This guy already looks like a rock star and is shaping up pretty well to create history. The smartphone is rumored to flaunt edge-to-edge display and come with the most talked about feature of iPhone X—Face ID. It will feature an aluminum frame and a single lens camera. Despite having such impressive features, the starting price of the smartphone is said to be just $ 699.

A large number of prospective iPhone users had been waiting in the wings to upgrade to a new iPhone. Though many of them went for the upgrade, a huge group of people stayed away as they didn’t want to pay a hefty price for the radically designed smartphone that was yet to go through the grind.

Now that the iPhone X has been widely appreciated and features like Face ID and gesture bar have fully replaced Touch ID and Home button, they are willing to go with the change. Better still, the price of the smartphone doesn’t seem to be too high either.

“According to Kuo’s research note, shipment projections could fluctuate depending on the selling price of the 6.1-inch LCD iPhone, which Kuo believes will be somewhere between $ 700 and $ 800 in the United States. In his analysis, shipments will be around 105-115 million units when priced at US$ 699, and 95-105 million units when priced at US$ 799.”MacRumors

The analyst expects the 6.1-inch LCD iPhone will alone account for around 50 percent of the new iPhone line-up’s shipments. He further says that the sales will remain strong into 2019.

Going by this forecast, I wouldn’t be shocked if the lifetime sales of 2018 iPhones could reach approximately 200-250 million units.

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